Cancer as a metabolic disease

Cancer as a metabolic disease

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supportin...

Cancer as a mitochondrial metabolic disease

Cancer is widely considered a genetic disease involving nuclear mutations in oncogenes and tumor suppressor genes. This view persists despite the numerous inconsistencies associated with the somatic mutation theory. In contrast to the somatic mutation theory, emerging evidence suggests that cancer is a mitochondrial metabolic disease, according to the original theory of Otto Warburg. The findin...

Dogs as Disease and Cancer Detectors: A Literature Review

A Review of Neck Circumference As a Potent Anthropometric Predictor of Cardiovascular Disease and Metabolic Syndrome

Introduction: Obesity is considered to be a major risk factor for metabolic syndrome (MetS). The present study aimed to investigate the associations of neck circumference (NC) with cardiovascular diseases and MetS in adults. Methods: This review was conducted via searching in databases such as Medline, PubMed, Scopus, and Google Scholar using various keywords, ...

Cancer as a metabolic disease: implications for novel therapeutics

Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can...